Introduction in Alex Guarnaschelli’s Style:

There’s pot roast, and then there’s Mississippi Pot Roast. The kind that’s fall-apart tender, packed with rich, savory flavor, and dripping in a buttery, tangy sauce that makes you want to dunk an entire loaf of bread into it.

The beauty of this dish? It takes almost no effort. Just throw a marbled chuck roast into a slow cooker with ranch seasoning, au jus mix, butter, and those magical pepperoncini peppers, and let time do the rest. The result? Melt-in-your-mouth beef infused with bold, zesty, and buttery flavors.

If you’re looking for a foolproof, insanely delicious comfort meal, this Mississippi Pot Roast is the only recipe you need.

Recipe Resume in Todd Wilbur’s Style:

This Mississippi Pot Roast is rich, juicy, and packed with a deep, buttery flavor. The secret? Slow-cooking a well-marbled chuck roast with ranch seasoning, au jus mix, butter, and tangy pepperoncini peppers.

With only 5 ingredients and zero prep, this dish is a set-it-and-forget-it masterpiece—guaranteed to be the most flavorful pot roast you’ve ever had!

Exciting Story:

I’ll never forget the first time I made Mississippi Pot Roast—I was skeptical. Could something this simple really be that incredible? But the moment I lifted the lid on the slow cooker, I knew. The aroma alone was intoxicating.

Then, I took that first bite—rich, buttery beef with a hint of tang from the pepperoncinis, all bathed in a ridiculously flavorful sauce. It was game over. Now, I make this at least once a month, and it never lasts more than a day.

Why This is the BEST Mississippi Pot Roast

🥩🔥 Juicy, Flavor-Packed & Effortless!

✔ Only 5 ingredients—zero prep work!
✔ Slow-cooked until fork-tender & juicy.
✔ Incredibly flavorful with butter, ranch & au jus.
✔ A little tangy, a little salty, and completely addictive!
✔ Perfect for sandwiches, tacos, or over mashed potatoes!

Cuisine: Southern / Comfort Food

Tips for the Best Mississippi Pot Roast

✔ Use a well-marbled chuck roast – More fat = more tenderness and flavor.
✔ Don’t add water or broth – The beef releases its own juices while cooking.
✔ Want it less salty? – Use unsalted butter and low-sodium seasoning mixes.
✔ Prefer a thicker sauce? – Stir in 1 tablespoon cornstarch mixed with 2 tablespoons water at the end.
✔ Love spice? – Add extra pepperoncini peppers or red pepper flakes!

Substitutions and Variations

🔹 No au jus mix? – Use 1 tablespoon beef bouillon powder + 1 teaspoon cornstarch.
🔹 No ranch mix? – Mix ½ teaspoon dried dill, ½ teaspoon garlic powder, ½ teaspoon onion powder, and a pinch of salt.
🔹 Dairy-Free? – Swap butter for vegan butter or olive oil.
🔹 Low-Carb? – Serve over cauliflower mash or roasted veggies.

Make a Healthier Version

✅ Use grass-fed beef – More nutrients and better flavor.
✅ Reduce butter to 4 tbsp – Still rich, but slightly lighter.
✅ Skip the seasoning packets – Use homemade spice blends for less sodium.
✅ Add extra veggies – Carrots, mushrooms, or onions soak up all the goodness!

Closing in Todd Wilbur’s Style:

And there you have it—the ultimate Mississippi Pot Roast that’s juicy, buttery, and melt-in-your-mouth delicious!With only 5 ingredients and a slow cooker, this is comfort food at its best—no fuss, all flavor.

Make it today, and watch your family go crazy for it!

Relevant Categories:

Slow Cooker Comfort Food
Easy One-Pot Meals
Southern-Style Beef Dishes
Best Ever Pot Roast Recipes